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Lean tirzepatide when: Maximum weight loss is the goal (target greater than 20%) You have T2D with significant insulin resistance (SURPASS-2: 11.2 kg tirzepatide vs 5.7 kg semaglutide) You have moderate-to-severe obstructive sleep apnea with obesity (Zepbound is the only FDA-approved pharmacotherapy) You plateaued on semaglutide after 12+ months You have MASH and need the drug with the strongest resolution data (SYNERGY-NASH: 44 to 62% resolution) Your insurance covers Zepbound or Mounjaro You tolerated the 2.5 mg starting dose well during a prior trial Lean semaglutide when: You have established cardiovascular disease or high CV risk

It is not approved for human or veterinary therapeutic use by any national medicines regulatory authority, including the EMA, FDA, or MHRA

9 However, a more recent review and analysis suggests that combination of pioglitazone with a GLP-1 receptor agonist or SGLT2 inhibitor is associated with weight loss and a reduced risk of heart failure

Ultimately, Hers Weight Loss offers a structured, accessible option for those committed to making sustainable health changes, but it may not be ideal for everyone