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In vivo , FTO knockdown significantly elevates YTHDF2 expression in the striatum of PD mice, inhibits m 6 A demethylation of BAP1 and reduces BAP1 expression, upregulates SLC7A11 expression, decreases -Syn, MDA, Fe 2+ , and 4-HNE levels, suppresses neuronal ferroptosis and disruptions in the amino acid antioxidant system, and promotes dopaminergic neuronal survival in PD mice (Li et al., 2025c)
PubMed Kang, E.A., Han, Y.M., An, J.M., Park, Y.J., Sikiric, P., Kim, D.H., Kwon, K.A., Kim, Y.J., Yang, D., Tchah, H., & Hahm, K.B
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Anything that saturates tissue copper stores may blunt the gradient that drives copper release from GHK at wound sites
