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By the time most patients notice visible changes in skin texture, hair density, or how quickly they recover from injury, the peptide that was quietly managing those processes has been declining for years

Gaps in safety assessment encompass limited long-term data in vulnerable populations, an incomplete understanding of horizontal gene transfer related to antimicrobial resistance, and uncertainty regarding the systemic impact of prolonged microbiome modulation, particularly with next-generation strains lacking a long history of safe use (142)

The acceleration of cell turnover caused by tretinoin pushes impurities to the surface more rapidly, resulting in a temporary increase in acne, whiteheads, and blackheads lasting anywhere from 4-6 weeks

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