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When your cells literally lack the molecular shuttles required to produce basic energy, the profound fatigue you experience is not a lack of willpower, motivation, or fitnessit is a very real, measurable physiological deficit
Activation of p53 by MDM2-inhibition sensitizes quiescent blast crisis CML stem/progenitor cells to Bcl-2 inhibitor- and tyrosine kinase inhibitor-induced cell death
doi: 10.1007/s10072-019-04021-z
Conflict of interest The author is an advisor to several regulatory agencies and governments
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