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Additionally, peptide DSIP has been shown to interact with the hypothalamic-pituitary-adrenal (HPA) axis, which plays a crucial role in stress adaptation and immune function
However, the analysis of the gut microbiota using NGS after a single administration of GLP-1RA has not been studied, and this is a subject for further study
The CSF-to-plasma ratio is approximately 0.4%, confirming that a small but definite amount of the drug penetrates the central nervous system (CNS) (Scheltens et al., 2026)
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