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The ratio of fat-mass loss to lean-mass loss was similar to that reported in lifestyle-based intervention in the Look AHEAD trial (241) and surgical treatment for obesity (242)

The trial program has evolved from glycemic-safety and outcomes studies in T2D (the LEADER, SUSTAIN-6, REWIND, EXSCEL, and PIONEER 6 era [10][13], [19]), to outcomes trials in expanded populations including obesity without diabetes (SELECT [3]), HFpEF with obesity (SUMMIT [5], with a companion semaglutide program in STEP-HFpEF [20], [21]), CKD (FLOW [22]), and an active-comparator setting (SURPASS-CVOT [6])

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Space alcohol and your injection by at least 24 hours when possible to minimize overlapping GI stress