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They should not be co-prescribed with DPP-4 inhibitors as this combination provides no additional benefit

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Measurement of intact GLP-1 is compromised by its concentration below the detection limit of the assay due to its extremely rapid degradation by DPP-IV enzyme (1)

However, other studies have implied that multiple IgG molecules can bind to the same pathogen and that the antibody array on the surface of pathogen allows for multivalent interactions with the mucin network, creating an avidity effect sufficient to effectively trap pathogens 85