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The more known incretins are glucagon like peptide-1 (GLP-1) and Gastric insulinothropic peptide (GIP)
1, 2 IGF-1R is primarily activated by its high-affinity ligands, IGF-1 and IGF-2, though it can also bind insulin with lower affinity
This mimics your bodys natural rhythm of growth hormone release often referred to as biological GH mimicry. Ipamorelin promotes a controlled growth hormone pulse, without significant stimulation of hunger or adrenal axis disruption, making it superior to earlier GHRP compounds. Patel et al., Endocrine Reviews Unlike exogenous human growth hormone (HGH) , which suppresses natural production over time, Ipamorelin does not cause negative feedback loop suppression
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