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The structure of GPXs Although GPX1, GPX3 and GI-GPX2 are homotetramers, the GPX4 is a monomer with a molecular size smaller than the subunits of other glutathione peroxidases
Mitochondrial glutathione depletion is directly linked to oxidative damage to mitochondrial DNA, impaired cellular energy production, and the patterns of age-related functional decline observed across tissues
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