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For hepatic specification, the study identified a novel small-molecule cocktail, VDF (Vitamin C, Dihexa, and Forskolin), that could effectively substitute for expensive growth factors like BMPs, FGFs, and HGF

doi: 10.3389/fphar.2025.1528208 Received 14 November 2024 Accepted 02 April 2025 Published 10 April 2025 Volume 16 - 2025 Edited by Yanggan Wang, Wuhan University, China Reviewed by Yi Zhu, Chengdu University of Traditional Chinese Medicine, China Baonian Liu, Shanghai University of Traditional Chinese Medicine, China Updates Copyright 2025 Chen, Fu, Zhou and Wu