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To improve selectivity, nanoplatforms can incorporate conditional activation mechanisms

Journal of Controlled Release, 87(13), 187198

Metz TO, Qian WJ, Jacobs JM et al (2008) Application of proteomics in the discovery of candidate protein biomarkers in a diabetes autoantibody standardization program sample subset

As a triple incretin receptor agonist, it: Activates GLP-1 receptors , reducing appetite, slowing gastric emptying, and improving insulin secretion Activates GIP receptors , enhancing insulin response and potentially supporting fat metabolism Activates glucagon receptors , increasing energy expenditure and hepatic glucose output Whilst glucagon receptor activation increases hepatic glucose output, the net glycaemic effect of retatrutide is mitigated by the concurrent GLP-1 and GIP activity, resulting in overall improvements in glycaemic control in trial participants