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NM_002084.3), in which the codons for Cys-12 (TGC), Cys-81 (TGC) and Cys-136 (TGT) were replaced with the codons for Ser (TCG) and the codon for Sec-53 (TGA) was changed to Cys codon (TGC)

A complicating factor in clinical trials has been the significant inter-individual variability in susceptibility to APAP toxicity 14

Host interactions have been shown to induce persister formation in numerous pathogens, with the production of reactive oxygen and nitrogen species heavily implicated in the collapse of bacterial metabolic activity and entry into an antibiotic-tolerant state

Acute decompensated cirrhosis: these patients differ markedly from ALF in baseline liver function, etiologies, precipitants, workup, management, and complications