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Indication and Usage RYBELSUS (semaglutide) tablets 7 mg or 14 mg is indicated: as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes to reduce the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction or non-fatal stroke) in adults with type 2 diabetes mellitus who are at high risk for these events References: RYBELSUS [package insert]

Moreover, it is known that in arteriosclerosis model mice, GLP-1 signaling increases the expression of eNOS which leads to the dilatation of blood vessel 8

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Beyond that, we anticipate identification of novel targets and techniques for therapeutic intervention