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Despite being discovered first, it received less clinical attention for decades because early research suggested that GIP signaling was impaired in type 2 diabetes, making it seem like an unlikely therapeutic target
p63 is a stem cell marker that belongs to a family that includes two structurally related proteins, p53 and p73 [16], while PCNA, which is present in proliferating cells throughout the cell cycle, is a well-established marker of proliferating cells [17]
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