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it is generally characterized by increased intracellular free iron content, the accumulation of reactive oxygen species (ROS), and lipid peroxidation [19, 20]

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3.2 Patient-reported outcome measures (PROMs) As summarized in Table 2, HA + GSH-C4 treatment was associated with a reduction in OSDI scores (control formulation: 25.26 0.05 vs

In trauma and hemorrhagic shock models, elevated circulating mtDAMPs levels correlate with injury severity and drive a SIRS that clinically mimics sepsisa phenomenon termed sterile sepsis or autosepsis. Notably, experimental administration of purified mtDAMPs is sufficient to recapitulate neutrophil-mediated organ injury and hemodynamic collapse, establishing a direct causal link between IR-induced mitochondrial disruption and SIRS-like systemic inflammation ( The IR-mtDAMPs axis creates a feed-forward amplification loop: IR injury causes mitochondrial damage and mtDAMPs release