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Unfavorable physicochemical properties PROTACs are heterobifunctional molecules composed of two protein ligands connected by a linker, resulting in molecular weights that substantially exceed those of conventional small-molecule drugs, typically approaching ~1000 Da and thus violating Lipinskis Rule of Five [61,62,63,64]
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Impact of medication on protein and amino acid metabolism in the elderly: the sulfur amino acid and paracetamol case
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