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Mitophagy is suppressed via PINK degradation, promoting macrophage polarization of the proinflammatory phenotype M1 and the development of AS (Hung et al., 2021)

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Was a human pharmacokinetic study performed

While BPC-157 has shown some interesting results in laboratory rodent studies for tendon and soft tissue healing, there are zero peer-reviewed, long-term clinical trials on its safety or efficacy in dogs, she says