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Hyperglycemia and lipotoxicity drive sustained ROS production through NADPH oxidase (NOX4), mitochondrial respiratory chain complexes I and III, and xanthine oxidase, while concurrently depleting antioxidant defenses such as glutathione (GSH), superoxide dismutase (SOD2), and catalase
GLUTATHIONE IN ENDOPLASMIC RETICULUM In ER, glutathione exists mainly as oxidized glutathione (GSSG)
Similarly, recreational drugs, including cannabis, can significantly impair sperm production and quality
10.1093/jnci/djx012 19 CasesA
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