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The inflammatory link between psoriasis and systemic health is underscored by reduced lifespan among those afflicted with this disease: moderate-to-severe psoriasis patients have a 5-year diminished life expectancy

These two enzymes are involved in the biosynthesis of allopregnanolone (ALLO) and tetrahydrodeoxycorticosterone (THDOC)

The medications most commonly associated with this issue include semaglutide (sold as Ozempic and Wegovy), tirzepatide (Mounjaro and Zepbound), retatrutide , and oral GLP-1 formulations

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