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Besides inhibiting the Xc- antiporter, erastin is also an activator of the mitochondrial voltage-dependent-anion channel (VDAC) by reversing the inhibitory effect of tubulin on VDAC, thus increasing oxidative phosphorylation, ATP, ROS production and mitochondrial membrane permeabilization

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In these situations, patients may have high B12 on blood work but still exhibit neurological symptoms of deficiency (tingling, numbness, cognitive changes)

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