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In a prospective study, Sabate et al.[39] estimated the incidence of acute liver injury due to therapeutic dosages of APAP to be about 10 per million user-years

In fact, enzymes involved in neuromuscular activity (i.e., the ATPase enzymes that transport of sodium, potassium, and calcium ions) are apparently most sensitive to magnesium deficiency (69)

40,41 However, high doses of glutathione for prolonged periods may cause chronic toxicity and carry some risks like zinc depletion, hypersensitivity, drug interactions, teratogenicity, etc

It is important to have blood work performed prior to beginning this medication to assess liver and kidney function as well as assist in identifying any additional underlying health conditions