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Pathogenesis of renal anemia
Some species of plants have a variant of glutathione, homoglutathione, in which the glycine residue is replaced by b-alanine, due to an evolutionary change in specificity of the enzyme glutathione synthetase
The research team identified that erastin could directly bind to VDAC2/3, leading to loss of mitochondrial function as well as the emission of substantial amounts of oxides, finally causing ferroptosis (Yagoda et al., 2007)
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