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April 15, 2026
When a patient on a stable transdermal estradiol regimen cannot fill her prescription because patches are on backorder, the prescriber faces a clinical decision: switch to an oral formulation (with a different risk profile), switch to a different delivery system the patient hasnt used before, or consider a compounded transdermal estradiol preparation that delivers the same active ingredient through the same route
EX long-acting preparation can reduce weight, but there are few related clinical studies, and most focus on patients with T2DM
Oral supplements may support long-term maintenance
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