Comparative effects of GLP-1 and GLP-2 on beta-cell function, glucose homeostasis and appetite regulation
Routine follow-up should address: Tolerance of gastrointestinal side effects, weight loss trajectory and nutritional adequacy, blood glucose patterns for patients with diabetes, and any new or concerning symptoms even if seemingly unrelated to the medication
Together, these observations suggest that receptor-level signaling and anti-inflammatory effects alone may be insufficient to produce functional improvement in energy-demanding tissues such as skeletal muscle and brain, where substrate turnover and mitochondrial metabolic throughput are critical determinants of tissue function
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