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Starting from the square-cube law equations [1] [2] , an equation for the change in brain volume proportional to the change in brain surface area [6] was derived

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194 This result was consistent with the accumulation of CSA in patient-derived low-grade glioma and with the intra-tumoural expression of CDO1, 76 since the decreased level of cysteine can be due to the overexpression and activity of CDO1 found in high-grade glioblastomas