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Effect of SP and L-car on mRNA expression of ovarian SIRT1 following DOX-mediated POI rats SIRT1 levels were measured in ovarian samples as a master regulator of cytoprotective pathways in POI rats by the qRT-PCR method
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However, their effects are dose- and context-dependent, for instance, moderate supplementation enhances fertility, while excessive levels may disrupt normal physiological ROS signaling (Manful et al., 2025)
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