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High Dose Requirement and Side Effects : Effective dosages of L-arginine are typically quite high, often causing digestive distress such as bloating, nausea, or diarrhea, reducing compliance and comfort in use
Subcutaneous injection into abdominal adipose tissue (12 inches lateral to the navel) provides consistent absorption kinetics and is the standard site for peptide administration
It does not appear toxic, does not accumulate in tissues, and has been well tolerated in trials
Muhammad J
![Efficacy of tirzepatide in phase 2 (GPGB; [14]) and phase 3 (SURPASS-1](https://www.researchgate.net/publication/363201315/figure/fig3/AS:11431281082605778@1662084799021/Efficacy-of-tirzepatide-in-phase-2-GPGB-14-and-phase-3-SURPASS-1-to-5-15-19.png)
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