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Allosterics are great because they are usually very selective, says Unitt, youll probably have a very good, clean drug. In 2024 Roche acquired Carmot Therapeutics, whose once-daily oral small molecule GLP-1 drug CT-996 was designed to have better signalling bias, meaning it preferentially triggers cellular pathways that lead to insulin regulation

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Sources: Pekala J, Patkowska-Sokoa B, Bodkowski R, Jamroz D, Nowakowski P, Lochyski S, Librowski T

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