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89 In addition to ONOO -mediated oxidation of BH 4 , there may be also an intracellular decrease because of decreased synthesis by inhibition of the GTP cyclohydrolase I ( de novo synthetic pathway) or by inhibition of the so-called salvage pathway involving enzymes such as the sepiapterin synthase, the sepiapterin reductase or the dihydrofolate reductase

We use XPPAUT (Ermentrout, 2002) for model simulations and MATLAB (Guide, 1998) for the analysis of our data

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