Several studies have shown that complete withdrawal of an obesity treatment dose of a GLP-1RA without other structured care leads to weight regain in most people.2 However, it remains unclear whether lifelong treatment of obesity should always consist of GLP-1RAs at full obesity dosing or whether a range of alternative strategies can enable some subset of people with obesity to maintain their weight loss after a limited duration of initial treatment, followed by tapering, discontinuing, or off-ramping these agents." This paragraph from the article, I believe, sums up nicely what this means
A substantial body of evidence from animal studies [92,93,94,95] and clinical trials [96,97,98,99,100,101] indicates that GLP-1 RAs have a marked effect in ameliorating myocardial ischemia, reducing reperfusion injury, decreasing infarct size, and enhancing cardiac function
its a physiological reality
Laser surgery: A surgical procedure that uses a laser beam (a narrow beam of intense light) as a knife to make bloodless cuts in tissue or to remove a surface lesion such as a tumor
