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NICE guidance supports their use in type 2 diabetes for people with established cardiovascular disease or high cardiovascular risk, or when additional therapy is needed despite metformin and/or SGLT2 inhibitors
The pace of loss accelerated between weeks 12 and 24, peaking at roughly 0.8 kg per week, and by the halfway mark, the average stood at 17.3%
In the databases of adverse drug events in multiple countries, the number of reports of mood changes, suicidal ideation and depression related to GLP-1RA has been on the rise, prompting regulatory authorities to request further monitoring [13, 15, 26, 27]
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