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doi: 10.1016/j.molmet.2020.101102 15 TuXKChenQChenSHuangBRenBGShiSS

To illustrate magnitude (modeled estimate), applying these usage rates to 2025 adult population estimates suggests 28M+ adults in the U.S

Originally developed for type 2 diabetes management under the brand name Ozempic, a higher-dose formulation called Wegovy was approved in 2021 specifically for chronic weight management in adults with obesity or overweight with weight-related health conditions

Additionally, we assigned biologically informed weights to the edges of the constructed comorbidity network to reflect the functional relevance of pathway interactions in DM2AD comorbidity formation