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Stable isotope tracing, oxygen consumption, enzyme activity, mitochondrial respiration, and tissue imaging can clarify whether a metabolite change reflects altered production, utilization, transport, or clearance
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GLP-1s and Addiction The authors of GLP-1 Therapeutics and Their Emerging Role in Alcohol and Substance Use Disorders: An Endocrinology Primer , appearing in October 2025 in JES, point out that the World Health Organization reported 890 million adults and 60 million children and adolescents had obesity in 2022 globally
Synaptic Dysfunction and Memory Loss in Depression and Its Relation to GLP-1 In patients with depression, neural circuits are impaired as a result of aberrant communication between neurons (Williams, 2016)
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