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As the main substrate of lipid peroxidation released from PL in the cell membrane, AA is a precursor of proinflammatory mediators that can be metabolized by cyclooxygenases (COX), ALOX, and CYP450 monooxygenases to synthesize biologically active inflammatory mediators, such as prostaglandins (PGs) and leukotrienes [91]
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Asmar A, Simonsen L, Asmar M, Madsbad S, Holst JJ, Frandsen E, et al
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