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Five-day dosing pushes concentrations above the tested therapeutic window
This demonstrates that the drug has effects that go beyond the reduction of adipose tissue, or so-called pleiotropic effects. He added that mechanisms underlying such an effect might include improvements in inflammation, oxidative stress and endothelial function via direct activation of GLP-1 receptors in the arterial wall, but this needed further investigation
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Bagno LL, Kanashiro-Takeuchi RM, Suncion VY, et al
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