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Anxiety-like behavior - In mice, supplementation with NAC from G12- P1 [96] or pre-mating until G16 [95] did not have an effect on PRS-induced anxiety-like behavior in the EPM at W10-14 [96] or in the OFT and EPM at P33-50 [95]

Detecting Zepbound Eye Problems Early: Patients starting treatment with tirzepatide must have structured surveillance protocols in place to detect eye complications as early as possible

Patients and clinicians should be aware that reflux-type symptoms are biologically plausible and have been reported in trial settings for this drug class, even if a definitive causal link has not been formally established for retatrutide specifically