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Blood-brain barrier breakdown and neovascularization processes after stroke and traumatic brain injury
Supporting a dominant role for diet composition in establishing the Firmicutes : Bacteroidetes ratio, previous work has shown that mice maintained on a high-fat diet had a similar cecal Firmicutes : Bacteroidetes ratio to those maintained on a high-carbohydrate diet 77
The NRF2-dependent effect was identified through the antioxidative response element in target gene loci, while NRF2-independent effects act through DNA 5hmC modifications via the regulation of the metabolite L2HG
Thomas Ruiz, OB/GYN lead at MemorialCare Orange Coast Medical Center in Fountain Valley, CA, not involved in this study, expressed some caution about the findings, but also a measure of hope: Its too soon to extrapolate to humans
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