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In our opinion, the well-note PsA comorbidities could have a minor impact on BCAAs unbalance (not all patients develop metabolic syndrome), with a greater effect of arthritis as the primary symptom of our cohort: we can suppose that reported results are inflammation-driven, and the activated catabolism associated with this condition, contributes to the decreased BCAAs circulating levels, maybe because an higher uptake of these amino acids to fuel the immune response and cellular metabolism

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The metabolomics profiles of severe COVID-19 patients and patients with advanced cancer are similar, and in high-risk patients, SARS-CoV-2 infection leads to aberrant STAT3 activation, which promotes a cancer-like metabolism

Black participants are underrepresented, whilst Asian populations are overrepresented relative to the US population