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The mechanism by which CGI1746 inhibited ferroptosis was found to be its chaperone, sigma-1R (1R), a receptor located on the mitochondrial membrane
These properties make it particularly relevant in contexts where oxidative stress drives tissue damage: photoaging, COPD, post-injury inflammation, and metabolic disease
Jimnez et al., 1998) and PRXIIF ( 2 reduction to water and dissipation of energy in form of heat (Rasmusson and Wallstrm, 2010
The precursor m/z range was configured from 100 to 1700, and fragment m/z from 100 to 1500
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