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This is in line with the fact that the processes driving R 2 relaxation arise from interactions between nuclear spins within the molecule and are sensitive to slower motions, such as internal motions (e NOEs, R 1 , and R 2 relaxation rates for p53 194 in presence and absence of FOXO4-DRI

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Symptom improvement is usually noticeable inside three to four weeks, with the steepest gains during the loading phase