This essential coenzyme of ThDP-dependent enzymes is absolutely necessary not only for oxidative glucose metabolism, but also for coupling metabolic pathways of carbohydrates and amino acids, as well as for controlling de novo synthesis of major neurotransmitters, ACh and glutamate, from glucose
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10.2337/dc12-2709 61 RosenstockJ.HanefeldM.ShamannaP.MinK