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Increased respiratory water loss and the diuresis often seen in the early response to altitude exposure can create a significant increase in water requirements at the same time that reduced thirst and changes in fluid availability in a new environment may alter usual drinking practices [2, 24, 25]
This includes starting with big doses, then keeping up with smaller ones
Cell Mol Biol (Noisy-le-grand) 2007
Second, sequential enhancement where one peptide creates conditions that enhance the effectiveness of others
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