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First Month on Retatrutide The first few weeks usually bring the most noticeable retatrutide side effects

Rapid weight loss can disrupt oestrogen levels and the hypothalamic-pituitary-ovarian axis, potentially causing irregular periods or temporary amenorrhoea

These ranges are wide because individual response varies enormously based on starting BMI, metabolic health, adherence, and concurrent lifestyle modifications

It was characterised as the first selective compound of its class, meaning it stimulates growth hormone release with comparatively little effect on cortisol and prolactin (Raun et al., European Journal of Endocrinology , 1998)