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For vitamin B 12 labeling purposes, 100% of the daily value was 6.0 g, but on 27 May 2016, it was revised downward to 2.4 g (see Reference Daily Intake)
In addition, mRNA expression of key genes in lysosomes, including acid hydrolases (such as cathepsin A/D), LAMP-1 and LAMP-2, was significantly upregulated following sepsis, hinting that overloaded lysosomal function might be an early marker for poor outcomes for patients with sepsis 22
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