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They cause inflammatory reactions and can be dangerous even in small amounts

Serious Precautions Boxed warning (thyroid C-cell tumors in rodents): Avoid in patients with MEN2 or personal/family history of medullary thyroid carcinoma (MTC)

At longer follow-up through week 104, greater waist circumference reduction and, to a lesser extent, a modest trend toward lower MACE with greater weight loss in the semaglutide group were associated with lower in-trial MACE incidence, whereas no consistent linear relationship was observed in the placebo group

417 Chronic stress additionally down-regulates astrocytic expression of AQP4