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Clinical trials support safety and efficacy at this level, though many patients achieve excellent results at lower doses between 0.5 and 1.7 mg

Research suggests that the hormonal and metabolic factors that contribute to weight gain, including elevated ghrelin levels and reduced satiety signaling, tend to reassert themselves after discontinuation

Because the drug lingers in the body for so long, skipping a dose occasionally does not cause severe side effects, says Tatiana Figueredo-Dietes, MD, an obesity medicine physician at NYC Health + Hospitals, Bellevue

If more than four days have passed, skip the missed dose and wait to take your next dose on the regular day