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Upon signal stimulation, PGC-1 is activated and translocated into the nucleus, where it acts as a transcriptional coactivator to activate nuclear factor E2-related factor 2 (Nrf2) [21]
doi: 10.1007/s12011-023-03616-0 27 DaragAKlimczakMStragierowiczJStasikowska-KanickaOKilanowiczA
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Combination or titration arms help establish whether balanced multi-agonism yields supra-additivity or simply layers independent effects
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