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As GPX4 serves as the master regulator of lipid hydroperoxide reduction, its suppression triggers irreversible lipid peroxide accumulation that culminates in ferroptotic cell death (67, 68)

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Here are the needs by age: 0 to 6 months - 40 mg 7 to 12 months - 50 mg 1 to 3 years - 15 mg 4 to 8 years - 25 mg 9 to 13 years 45 mg 14 to 18 years - 75 mg for males and 65 mg for females 19 + years - 90 mg for males and 75 mg for females (Source 2, 3) These needs represent the recommended dietary allowances (RDAs), although you can safely take higher dosages with supplements