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Mechanistically, it activates Nrf2 and its nuclear translocation, thereby enhancing the expression of downstream antioxidant genes to relieve oxidative stress
To date, 731 participants have been enrolled to compare the long-term effects of tirzepatide versus placebo in improving major adverse cardiovascular events (MACE), weight, and metabolic indicators, and to assess its efficacy in enhancing exercise tolerance in heart failure patients
J., Widlansky, M
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