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Detectability is a crucial consideration in biomarker discovery, as proteins with excessive missing values or those undetectable in one group are typically excluded during data cleaning and differential analysis, potentially leading to missed findings
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This TME is defined by pervasive infiltrates of tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs), cancer-associated fibroblasts (CAFs), and a dense mineralized extracellular matrix (ECM) barrier that collectively exclude or exhaust cytotoxic T cells
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